Benfotiamine

Benfotiamine is a synthetic, lipid-soluble form of vitamin B1 (thiamine) that achieves significantly higher blood and tissue levels compared to standard thiamine supplements. Originally developed in Japan, it has been widely used in Europe for decades to address conditions linked to thiamine deficiency. It is particularly studied for its effects on nerve function, blood sugar metabolism, and protection against advanced glycation end products (AGEs).

Rhonda PatrickTakes it

Research Evidence

May reduce oxidative stress markers related to glucose metabolism

Moderate

May help reduce markers of advanced glycation end products (AGEs)

Moderate

Achieves higher bioavailability than standard thiamine

Strong

Supports peripheral nerve function in those with metabolic concerns

Moderate

Potential benefit for alcohol-related thiamine deficiency

Limited

Source: Examine.com

Expert Evidence

1 reference from 1 expert

Currently takes

“Benfotiamine, I'm taking that by Life Extension.”

This Is Everything Rhonda Patrick Supplements With

0:50

Rhonda Patrick

1 reference in 1 episode from 2024

AI-generated summary

Rhonda Patrick takes benfotiamine, specifically the Life Extension brand. No dosage, timing, or rationale for use is provided in the available references.

2024

Safety & Cautions

Side Effects

Mild gastrointestinal discomfort
Skin rash in rare cases
Headache at higher doses

Benfotiamine is generally well-tolerated at standard doses with a strong safety profile across clinical studies. Those who are pregnant, nursing, or taking medications that interact with B vitamins should consult a healthcare provider before supplementing.

Pairs Well With

Alpha Lipoic Acid Vitamin B Complex Magnesium

Price Comparison

From $0.08/ct

NutricostBest Value

4.7

•120 ct

$0.08/ct

$9.99 total

Buy

Doctor's Best

4.6