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    Iron

    Iron is an essential trace mineral found abundantly in red meat, shellfish, legumes, and fortified grains. It plays a central role in oxygen delivery throughout the body and is a component of hundreds of enzymes involved in energy metabolism. Iron deficiency remains the most prevalent nutritional shortfall globally, particularly affecting women of reproductive age, growing children, and endurance athletes.

    Research Evidence
    May alleviate restless legs syndrome when ferritin is low
    Moderate
    Supports cognitive function and brain development in deficient populations
    Moderate
    Reduces fatigue in iron-deficient individuals
    Strong
    Improves exercise capacity in those with low ferritin
    Moderate
    Corrects iron-deficiency anemia and restores hemoglobin levels
    Strong

    Expert Evidence

    5 references from 3 experts

    Currently takes

    “I take some iron during menstruation.”

    This Is Everything Rhonda Patrick Supplements With

    3:28
    Rhonda Patrick

    1 reference in 1 episode from 2024

    AI-generated summary

    Rhonda Patrick takes iron supplementally during menstruation to compensate for blood loss. No specific dosage, brand, or form is mentioned, and no broader benefits or cautions are discussed.

    Recommends against

    “Iron supplements can interfere with zinc absorption. People may also develop inflammation of the stomach or gastritis and stomach lesions. People with higher levels of iron seem to have lower life expectancy.”

    Popular Supplements You Should NEVER Take

    5:51
    Brad Stanfield

    3 references in 3 episodes from 2022–2024

    AI-generated summary

    Brad Stanfield recommends against iron supplementation, citing interference with zinc absorption, risk of gastritis and stomach lesions, and an association between higher iron levels and lower life expectancy. He notes that studies on supplementing iron (along with other vitamins/minerals) to prevent cancer have been largely disappointing. He does acknowledge that low ferritin (below 50) may cause fatigue, exercise intolerance, restless legs, and neurologic/sleep disorders. No evidence of personal use or specific dosing guidance is provided.

    Discusses

    “Nutritional status becomes really critical for the brain. We can deal with poor nutritional status and the brain works just fine early in life, but if you're trying to maximize everything, we know vitamin D, iron status, magnesium, B vitamins, and omega-3s are important.”

    Dr. Tommy Wood: Enhancing Brain Performance & Preventing Dementia

    21:54
    Andy Galpin

    1 reference in 1 episode

    AI-generated summary

    Galpin identifies iron as one of several key nutrients critical for brain health, particularly as we age, noting that poor nutritional status becomes harder for the brain to compensate for over time. He does not discuss personal use, specific dosing, forms, or cautions related to iron supplementation.

    2024
    2022
    Safety & Cautions

    Side Effects

    • Constipation and stomach discomfort
    • Nausea
    • Gastric irritation or gastritis
    • Dark-colored stools
    • Potential interference with zinc absorption
    Iron is one of the few supplements where more is definitively not better — excess intake is associated with oxidative stress, organ damage, and potentially reduced longevity. Supplementation should only be undertaken when bloodwork confirms low iron or ferritin levels, and periodic retesting is advised.
    Pairs Well With
    Price Comparison
    From $0.04/ct
    N
    Nature MadeBest Value
    4.7
    180 ct

    $0.04/ct

    $7.06 total

    N
    Nature's Bounty
    4.5
    90 ct

    $0.10/ct

    $8.94 total

    N
    NOW Foods
    4.7
    90 ct

    $0.10/ct

    $9.30 total

    M
    MegaFood
    4.6
    180 ct

    $0.26/ct

    $45.99 total

    P
    Pure Encapsulations
    4.6
    60 ct

    $0.29/ct

    $17.60 total

    T
    Thorne
    4.7
    60 ct

    $0.35/ct

    $21.00 total