Ketone Esters
Ketone esters are synthetic compounds that deliver beta-hydroxybutyrate (BHB) directly into the bloodstream, rapidly elevating blood ketone levels within 15-30 minutes of ingestion. Unlike ketone salts that are bonded to minerals like sodium or calcium, ketone esters provide a concentrated dose of pure ketone bodies without added electrolytes. They are most actively studied for their potential in brain injury recovery, cognitive enhancement under metabolic stress, and endurance athletic performance.
Expert Evidence
4 references from 1 expert
“Ketones can bypass some of the mitochondrial dysfunction after brain injury and seem to be more energetically efficient in terms of generating ATP. They may also have anti-inflammatory and neurotrophic effects, including driving an increase in BDNF production which could help recovery.”
How Concussions Damage Your Brain | Dr. Tommy Wood & Dr. Andy Galpin
6:004 references in 2 episodes
Galpin discusses ketone esters exclusively in the context of brain injury recovery, noting they can bypass dysfunctional mitochondria, generate ATP more efficiently, and exert anti-inflammatory and neurotrophic effects including increased BDNF production. All four references are benefit claims related to TBI; there is no evidence of personal use, no dosing or product recommendations, and no cautions discussed.
Side Effects
- GI distress including nausea
- Bitter or unpleasant taste
- Stomach cramping at higher doses
- Transient diarrhea