Lion's Mane

500-1000mg

With meals

Lion's mane (Hericium erinaceus) is a large, white, shaggy edible mushroom that grows on hardwood trees and has been used in traditional East Asian medicine for centuries. It contains bioactive compounds called hericenones and erinacines that can cross the blood-brain barrier and are studied primarily for their neurological and cognitive benefits.

Research Evidence

Supports nerve regeneration and myelination

Moderate

Improves mild cognitive impairment in older adults

Moderate

Lowers inflammatory markers and cortisol

Limited

May protect against neurodegenerative disease progression

Limited

Stimulates nerve growth factor (NGF) production

Strong

Reduces symptoms of anxiety and depression

Moderate

Source: Examine.com

Expert Evidence

1 reference from 1 expert

Discusses

“There are good data showing that 1,000 milligrams of lion's mane per day can act as an adaptogen, reducing cortisol and anti-inflammatory cytokines like interleukin 6.”

AMA #3: Adaptogens, Fasting & Fertility, Bluetooth/EMF Risks, Cognitive Load Limits & More

17:17

Andrew Huberman

1 reference in 1 episode from 2023

AI-generated summary

Huberman cites data supporting 1,000 mg/day of lion's mane as an adaptogen that reduces cortisol and inflammatory cytokines like IL-6. He does not mention personal use, specific brands, timing, or any cautions.

2023

Safety & Cautions

Side Effects

Mild digestive discomfort
Skin rash in sensitive individuals
Possible allergic reaction in those with mushroom allergies

Lion's mane is generally well-tolerated with a strong safety profile in clinical studies. Those with mushroom allergies should avoid it, and individuals on anticoagulant or antiplatelet medications should consult a healthcare provider, as it may have mild blood-thinning properties.

Pairs Well With

Omega-3 Fatty Acids (EPA)Alpha-GPC Creatine Rhodiola Rosea

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